Perform YuGene normalization

This function performs YuGene normalization on an ExpressionSet. YuGene is a non-parametric normalization method that transforms expression data to a uniform distribution by computing cumulative proportions and applying a specific transformation.

Usage

YuGene(eset, verbose = TRUE)

Arguments

eset

An ExpressionSet object containing expression data.

verbose

Logical indicating whether to print progress messages and create density plots. Default is TRUE.

Value

An ExpressionSet object with YuGene-normalized expression data.

Examples

# Load example data and create ExpressionSet
expr_data <- load_example_expression_data()
meta_data <- load_example_metadata()
eset <- make_ExpressionSet(expr_data, meta_data)
#> ✓ ExpressionSet created successfully
#>   - Number of genes: 57010 
#>   - Number of samples: 24 


# Perform YuGene normalization
yugene_eset <- YuGene(eset, verbose = TRUE)
#> ✓ YuGene normalization completed